As the pivotal link between innovation and compliance in the pharmaceutical realm, the Data Computation Platform (DCP) enables the seamless integration of tools for non-GxP use and GxP-compliant advancements. Having undergone validation for GxP compliance, the DCP empowers robust real-time multivariate data analytics, showcasing its effectiveness in process monitoring through the AVEVA PI System as its primary data source. Transitioning from a closed system to an open-source, collaborative platform, the DCP embodies resilience, surmounting challenges to propel collective progress in the era of Pharma 4.0.